P-203: The Impact of Low-Dose Aspirin on Clinical Reproductive Outcomes in Frozen- Thawed Embryo Transfer Cycles; A Randomized, Placebo-Controlled Double- Blind Study
نویسندگان
چکیده مقاله:
Background: The objective of this study is to evaluate whether low-dose aspirin affects doppler sonographic parameters of the uterine arteries, endometrial thickness and pregnancy rate of women undergoing frozen-thawed embryo transfer cycles. Materials and Methods: This randomized, double- blind, placebo-controlled trial study was conducted between April 2012, and March 2013. A total of 60 eligible patients (aged 18-40 years) were randomly assigned to the study and control groups by using computer-generated random numbers. Allocation concealment was performed by using sealed envelopes. With the onset of endometrial preparation and estrogen treatment, the study and control groups received 100 mg of oral aspirin or placebo respectively. Doppler ultrasonography also was performed to calculate resistive index (RI) and pulsatility index (PI). The results of treatment cycle were compared in both groups. Results: There were no statistically significant differences between groups with regard to age and basal hormone levels. Both groups were comparable with respect to endometrial thickness on ET day and impedance indices (PI, RI) for both uterine arteries. Compared with placebo controls, aspirin group had a significantly higher pregnancy (p=0.045) and implantation rates (p=0.047). No statistically significant difference was detected in miscarriage rate between two groups. Conclusion: It seems that low-dose aspirin therapy positively affects pregnancy and implantation rates of women undergoing frozen- thawed embryo transfer cycles.
منابع مشابه
Effect of Progesterone Supplementation on Natural Frozen-Thawed Embryo Transfer Cycles: A Randomized Controlled Trial
متن کامل
Frozen-thawed embryo transfer cycles
In order to reduce the chance of multiple pregnancy during in-vitro fertilisation (IVF)– embryo transfer treatment, there is an increasing trend towards transferring a lower number of embryos. Surplus good-quality embryos are then transferred in frozen-thawed embryo transfer (FET) cycles. The first pregnancy after FET was reported in 1983.1 It has been estimated that in IVF programmes in which ...
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Background: The aim of this prospective randomized clinical trial was to determine the optimal endometrial preparation protocol by comparing the clinical outcome of two methods of endometrial preparation in FET cycles, that is, oral estradiol and 17 β-estradiol transdermal patch. Materials and Methods: A total number of 90 patients were scheduled for FET. In the study group (n=45), 17-B estradi...
متن کاملEmbryo stage of development is not decisive for reproductive outcomes in frozen-thawed embryo transfer cycles
OBJECTIVE To evaluate if the outcomes of IVF/ICSI in frozen-thawed embryo transfer and fresh embryo transfer cycles differ in relation to cleavage and blastocyst stages. METHODS Retrospective cohort study to compare IVF/ICSI outcomes between fresh embryo transfer and frozen-thawed embryo transfer cycles, according to the stage of embryo development. Analysis was carried out on 443 consecutive...
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متن کاملeffect of vitamin d insufficiency treatment on fertility outcomes in frozen-thawed embryo transfer cycles: a randomized clinical trial
background: frozen- thawed embryo transfer is an essential part of art treatment and outcomes of this procedure are associated with several clinical factors. several studies have showed an increase level of ivf outcomes in women with sufficient vitamin d. objective: whether treatment of vitamin d insufficiency can improve pregnancy rates in frozen-thawed embryo transfer cycles. materials and me...
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عنوان ژورنال
دوره 8 شماره 2.5
صفحات 214- 214
تاریخ انتشار 2014-07-01
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